Motor neuron disease (MND) refers to a group of progressive neurological disorders that affect motor neurons responsible for controlling voluntary muscles. The degeneration of these neurons leads to weakness, muscle wasting, and eventually paralysis. Amyotrophic lateral sclerosis (ALS) is the most common form, though variants include progressive bulbar palsy and primary lateral sclerosis.

The Motor Neuron Disease session focuses on cellular and molecular mechanisms underlying neuronal degeneration, including glutamate excitotoxicity, oxidative stress, mitochondrial dysfunction, and impaired axonal transport. Researchers also explore the role of protein misfolding and RNA metabolism in disease progression.

At the Motor Neuron Disease Conference, experts discuss diagnostic innovations, biomarker discovery, and emerging therapeutic strategies. Genetic breakthroughs—such as SOD1, TARDBP, and C9orf72 mutations—are paving the way for gene-targeted treatments. Topics also include neuroinflammation, stem-cell models, and clinical-trial results evaluating antisense oligonucleotides and neuroprotective agents.

This session welcomes neurologists, neuroscientists, geneticists, and rehabilitation specialists committed to improving outcomes for patients with motor-neuron degeneration. Attendees gain an in-depth understanding of translational approaches connecting lab findings to therapy.

Advances in Neural Repair and Regeneration research offer renewed hope, highlighting pathways to protect and restore damaged neurons.