Innovations in sutureless nerve repair: combining bioadhesives and electrical stimulation for enhanced outcomes

Peripheral nerve injuries (PNIs) remain a significant neurological hurdle, with clinical manifestations varying based on the degree of axonal disruption. While progress has been made in understanding the underlying mechanisms of nerve damage and regeneration, achieving full functional recovery remains a major unmet goal. Current nerve repair strategies often yield incomplete or delayed regeneration. This review highlights the emerging roles of bioadhesives and electrical stimulation (ES) in enhancing peripheral nerve repair, both as standalone treatments and in combination. Although preclinical studies show promising outcomes for these modalities in promoting axonal regrowth and functional recovery, clinical application is still in its early stages. Bridging the gap between laboratory success and clinical effectiveness is now essential to translate these nerve-targeted therapies into routine care.

Meet Peyman, a Doctor of Veterinary Medicine (DVM) graduate who is currently pursuing a Ph.D. in neurosurgery/neurosciences and biotechnology to evaluate the application of a biomaterial on sciatic nerve and spinal cord of rat, at WSU, Australia. Meanwhile, I am the laboratory manager and research assistant (RA) at School of Science, and I am certified to work with animals in Australia.